Kidney cancer (Renal Cell Cancer or RCC) is found in more men than women, usually in the 6th or 7th decade of one’s life. It is manageable 90-95% of the time.
This is an experimental procedure that comes with all kinds of warnings with it and is not confirmed as a proven procedure, most notably, that there are two significant risks and side effects.
The two noted in my research thus far include:
1. Cytokine-release syndrome (CRS)
A cytokine storm, also called hypercytokinemia, is a physiological reaction in humans and other animals in which the innate immune system causes an uncontrolled and excessive release of pro-inflammatory signaling molecules called cytokines. Normally, cytokines are part of the body's immune response to infection, but their sudden release in large quantities can cause multisystem organ failure and death. Cytokine storms can be caused by a number of infectious and non-infectious etiologies, especially viral respiratory infections such as H5N1 influenza, SARS-CoV-1, and SARS-CoV-2. Other causative agents include the Epstein-Barr virus, cytomegalovirus, and group A streptococcus, and non-infectious conditions such as graft-versus-host disease.
2. Neurological toxicity (NT)9
Neurotoxicity occurs when the exposure to natural or manmade toxic substances (neurotoxicants) alters the normal activity of the nervous system. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies, and organ transplants, as well as exposure to heavy metals such as lead and mercury, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness; loss of memory, vision, and/or intellect; headache; cognitive and behavioral problems; and sexual dysfunction. Individuals with certain disorders may be especially vulnerable to neurotoxicants.
Both of these adverse reactions can lead to sudden death.
If there is an adverse reaction to this therapy it will occur quickly within the first week, as per the research.
This is a clinical study that is going until 2027.
The lead investigator is
Matthias Will, MDCRISPR Therapeutics
Contact: Clinical Trials+1 (877) 214-4634
MedicalAffairs@crisprtx.com
It is a CAS9 / CRISPR Therapeutics led clinical trial utilizing CAR-T Cell therapies, specifically CTX130.
CRISPR
CRISPR (/ˈkrɪspər/) (clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral (i.e. anti-phage) defense system of prokaryotes.
Why is crisper bad?
The most-discussed safety risk with CRISPR is that the Cas9 enzyme, which is supposed to slice a specific DNA sequence, will also make cuts in other parts of the genome that could result in mutations that raise cancer risk.
The gene editor CRISPR won’t fully fix sick people anytime ...
www.sciencemag.org/news/2016/05/gene-editor-crispr …
_______________
Videos
What is CRISPR?
https://www.youtube.com/watch?v=R0RdwQVd2NY&feature=emb_logo
Genome Editing with CRISPR-Cas9
https://www.youtube.com/watch?v=2pp17E4E-O8
TED Talk
https://youtu.be/TdBAHexVYzc
TED Talk
https://youtu.be/47pkFey3CZ0
Cas9
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilo dalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids and which is heavily utilized in genetic engineering applications. Its main function is to cut DNA and therefore it can alter a cell's genome.
https://www.thermofisher.com/us/en/home/life-science/genome-editing/geneart-crispr/crispr-protein.html?cid=bid_clb_gme_r01_co_cp0000_pjt0000_bid00000_0se_bng_nt_pur_con&s_kwcid=AL!3652!10!77378255423995!77378305243900&ef_id=XeWzxAAAAHv2Qim5:20200809162800:s
https://www.thermofisher.com/us/en/home/life-science/genome-editing/genome-editing-learning-center/crispr-cas9-technology-information.html
CAR-T Cell
Chimeric Antigen Receptor
T-Cell therapies
This Clinical Trial is utilizing CTX130.
CTX130
CTX130 is a healthy donor-derived gene-edited allogeneic CAR-T therapy targeting CD70, an antigen expressed on hematologic cancers. A wholly-owned asset of CRISPR Therapeutics, CTX130 is in development for the treatment of both solid tumors, such as renal cell carcinoma, and T-cell and B-cell hematologic malignancies.
This is an experimental procedure that comes with all kinds of warnings with it and is not confirmed as a proven procedure, most notably, that there are two significant risks and side effects.
The two noted in my research thus far include:
1. Cytokine-release syndrome (CRS)
A cytokine storm, also called hypercytokinemia, is a physiological reaction in humans and other animals in which the innate immune system causes an uncontrolled and excessive release of pro-inflammatory signaling molecules called cytokines. Normally, cytokines are part of the body's immune response to infection, but their sudden release in large quantities can cause multisystem organ failure and death. Cytokine storms can be caused by a number of infectious and non-infectious etiologies, especially viral respiratory infections such as H5N1 influenza, SARS-CoV-1, and SARS-CoV-2. Other causative agents include the Epstein-Barr virus, cytomegalovirus, and group A streptococcus, and non-infectious conditions such as graft-versus-host disease.
2. Neurological toxicity (NT)9
Neurotoxicity occurs when the exposure to natural or manmade toxic substances (neurotoxicants) alters the normal activity of the nervous system. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies, and organ transplants, as well as exposure to heavy metals such as lead and mercury, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness; loss of memory, vision, and/or intellect; headache; cognitive and behavioral problems; and sexual dysfunction. Individuals with certain disorders may be especially vulnerable to neurotoxicants.
Both of these adverse reactions can lead to sudden death.
If there is an adverse reaction to this therapy it will occur quickly within the first week, as per the research.
This is a clinical study that is going until 2027.
The lead investigator is
Matthias Will, MDCRISPR Therapeutics
Contact: Clinical Trials+1 (877) 214-4634
MedicalAffairs@crisprtx.com
It is a CAS9 / CRISPR Therapeutics led clinical trial utilizing CAR-T Cell therapies, specifically CTX130.
CRISPR
CRISPR (/ˈkrɪspər/) (clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral (i.e. anti-phage) defense system of prokaryotes.
Why is crisper bad?
The most-discussed safety risk with CRISPR is that the Cas9 enzyme, which is supposed to slice a specific DNA sequence, will also make cuts in other parts of the genome that could result in mutations that raise cancer risk.
The gene editor CRISPR won’t fully fix sick people anytime ...
www.sciencemag.org/news/2016/05/gene-editor-crispr …
_______________
Videos
What is CRISPR?
https://www.youtube.com/watch?v=R0RdwQVd2NY&feature=emb_logo
Genome Editing with CRISPR-Cas9
https://www.youtube.com/watch?v=2pp17E4E-O8
TED Talk
https://youtu.be/TdBAHexVYzc
TED Talk
https://youtu.be/47pkFey3CZ0
Cas9
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilo dalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids and which is heavily utilized in genetic engineering applications. Its main function is to cut DNA and therefore it can alter a cell's genome.
https://www.thermofisher.com/us/en/home/life-science/genome-editing/geneart-crispr/crispr-protein.html?cid=bid_clb_gme_r01_co_cp0000_pjt0000_bid00000_0se_bng_nt_pur_con&s_kwcid=AL!3652!10!77378255423995!77378305243900&ef_id=XeWzxAAAAHv2Qim5:20200809162800:s
https://www.thermofisher.com/us/en/home/life-science/genome-editing/genome-editing-learning-center/crispr-cas9-technology-information.html
CAR-T Cell
Chimeric Antigen Receptor
T-Cell therapies
This Clinical Trial is utilizing CTX130.
CTX130
CTX130 is a healthy donor-derived gene-edited allogeneic CAR-T therapy targeting CD70, an antigen expressed on hematologic cancers. A wholly-owned asset of CRISPR Therapeutics, CTX130 is in development for the treatment of both solid tumors, such as renal cell carcinoma, and T-cell and B-cell hematologic malignancies.